Products

TMEM59 antibody

Synonyms:C1orf8 antibody
Catalogue No.:FNab08787Reativity:Human
Host:RabbitTested Application:ELISA, IHC, WB, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
TMEM59 antibody
Catalogue No.
FNab08787
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
transmembrane protein 59
Alternative Names
C1orf8 antibody
UniProt ID
Q9BXS4
Observed MW
41 kDa
Application
Tested Applications
ELISA, IHC, WB, IF
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab08787(TMEM59 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab08787(TMEM59 Antibody) at dilution of 1:50
Background
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3(MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.