Products

anti- THOC2 antibody

FNab08667 Catalogue No.
Synonyms
CXorf3
Host
Rabbit
Reactivity
Human
Isotype
IgG
Tested Application
ELISA, IP, WB, IF
Product Information
Product Name
anti- THOC2 antibody
Catalogue No.
FNab08667
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC2(and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.
Immunogen Information
Immunogen
THO complex 2
Synonyms
CXorf3
Observed MW
150 kDa
Application
Tested Application
ELISA, IP, WB, IF
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Uniprot information
UniProt ID
Q8NI27
Images
IP Result of anti-THOC2 (IP:FNab08667, 5ug; Detection:FNab08667 1:300) with HeLa cells lysate 1800ug.
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08667(THOC2 Antibody) at dilution of 1:300