Products
TEX14 antibody
- Product Name
- TEX14 antibody
- Catalogue No.
- FNab08609
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- testis expressed 14
- Alternative Names
- SGK307 antibody
- UniProt ID
- Q8IWB6
- Observed MW
- 180-200 kDa, 106 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab08609(TEX14 antibody) at dilution of 1:500
IP Result of anti-TEX14 (IP:FNab08609, 4ug; Detection:FNab08609 1:500) with mouse testis tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human testis using FNab08609(TEX14 antibody) at dilution of 1:50
- Background
- Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro(By similarity).
