Products
TELO2 antibody
- Product Name
- TELO2 antibody
- Catalogue No.
- FNab08592
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 8B6
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- TEL2, telomere maintenance 2, homolog
- Alternative Names
- KIAA0683 antibody
- UniProt ID
- Q9Y4R8
- Observed MW
- 92 kDa
Application
- Tested Applications
- ELISA, IHC, IF, IP, WB
- Recommended dilution
- WB: 1:1000-1:4000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab08592(TELO2 antibody) at dilution of 1:500
IP Result of anti-TELO2 (IP:FNab08592, 4ug; Detection:FNab08592 1:500) with HepG2 cells lysate 2900ug.
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab08592(TELO2 Antibody) at dilution of 1:200
- Background
- Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
