Products

anti- TBC1D5 antibody

FNab08515 Catalogue No.
Synonyms
KIAA0210
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC, IP
Product Information
Product Name
anti- TBC1D5 antibody
Catalogue No.
FNab08515
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
May act as a GTPase-activating protein (GAP) for Rab family protein (s) . May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837) . Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) ; the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992) . May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492) .
Immunogen Information
Immunogen
TBC1 domain family, member 5
Synonyms
KIAA0210
Observed MW
89 kDa
Application
Tested Application
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:2400; IP: 1:200-1:1000 ; IHC: 1:20-1:200
Uniprot information
UniProt ID
Q92609
Images
Immunohistochemistry of paraffin-embedded human kidney using FNab08515 (TBC1D5 antibody) at dilution of 1:100
IP Result of anti-TBC1D5 (IP:FNab08515, 4ug; Detection:FNab08515 1:300) with A431 cells lysate 2400ug.
A431 cells were subjected to SDS PAGE followed by western blot with FNab08515 (TBC1D5 antibody) at dilution of 1:400