Products

TBC1D5 antibody

Synonyms:KIAA0210 antibody
Catalogue No.:FNab08515Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
TBC1D5 antibody
Catalogue No.
FNab08515
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
TBC1 domain family, member 5
Alternative Names
KIAA0210 antibody
UniProt ID
Q92609
Observed MW
89 kDa
Application
Tested Applications
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:2400; IP: 1:200-1:1000 ; IHC: 1:20-1:200
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab08515(TBC1D5 antibody) at dilution of 1:400
IP Result of anti-TBC1D5 (IP:FNab08515, 4ug; Detection:FNab08515 1:300) with A431 cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab08515(TBC1D5 antibody) at dilution of 1:100
Background
May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).