Products
SYVN1 antibody
- Product Name
- SYVN1 antibody
- Catalogue No.
- FNab08463
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- synovial apoptosis inhibitor 1, synoviolin
- Alternative Names
- HRD1 antibody, KIAA1810 antibody
- UniProt ID
- Q86TM6
- Observed MW
- 68-76 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08463(SYVN1 antibody) at dilution of 1:1000
IP Result of anti-SYVN1 (IP:FNab08463, 4ug; Detection:FNab08463 1:1000) with mouse kidney tissue lysate 7200ug.
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab08463(HRD1 Antibody) at dilution of 1:200
- Background
- Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
