Products
SUPT16H antibody
- Product Name
- SUPT16H antibody
- Catalogue No.
- FNab08394
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- suppressor of Ty 16 homolog
- Alternative Names
- FACT140 antibody, FACTP140 antibody
- UniProt ID
- Q9Y5B9
- Observed MW
- 140 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab08394(SUPT16H antibody) at dilution of 1:300
IP Result of anti-SUPT16H (IP:FNab08394, 4ug; Detection:FNab08394 1:1000) with mouse brain tissue lysate 3440ug.
Immunohistochemistry of paraffin-embedded human tonsillitis using FNab08394(SUPT16H antibody) at dilution of 1:100
- Background
- Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2(casein kinase II).
