Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08321(STIM1 Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab08321(STIM1 Antibody) at dilution of 1:200(under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Background
Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores(By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+)(CRAC) channel subunit ORAI1(PubMed:16208375). Involved in enamel formation(By similarity). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch(By similarity).