Products
STIM1 antibody
- Product Name
- STIM1 antibody
- Catalogue No.
- FNab08321
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 4G6
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- stromal interaction molecule 1
- Alternative Names
- D11S4896E antibody, GOK antibody, STIM1 antibody, stromal interaction molecule 1 antibody
- UniProt ID
- Q13586
- Observed MW
- 77kd
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000IHC: 1:50-1:500
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08321(STIM1 Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab08321(STIM1 Antibody) at dilution of 1:200(under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores(By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+)(CRAC) channel subunit ORAI1(PubMed:16208375). Involved in enamel formation(By similarity). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch(By similarity).
