Products
STIM1 antibody
- Product Name
- STIM1 antibody
- Catalogue No.
- FNab08320
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- stromal interaction molecule 1
- Alternative Names
- D11S4896E antibody, GOK antibody, STIM1 antibody, stromal interaction molecule 1 antibody
- UniProt ID
- Q13586
- Observed MW
- 80kd
Application
- Tested Applications
- ELISA, WB, IP, IHC, IF, FC
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08320(STIM1 antibody) at dilution of 1:300
IP Result of anti-STIM1 (IP: FNab08320, 3ug; Detection: FNab08320 1:1000) with Raji cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab08320(STIM1 antibody) at dilution of 1:50
- Background
- STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.
