NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab08207(SPTLC2 antibody) at dilution of 1:1000
Background
Serine palmitoyltransferase(SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase(SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.