Products
SNAPIN antibody
- Product Name
- SNAPIN antibody
- Catalogue No.
- FNab08060
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SNAP-associated protein
- Alternative Names
- BLOC1S7 antibody, SNAP25BP antibody, SNAPAP antibody
- UniProt ID
- O95295
- Observed MW
- 15-18 kDa
Application
- Tested Applications
- ELISA, IF, WB, IHC, FC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
rat brain tissue were subjected to SDS PAGE followed by western blot with FNab08060(SNAPIN Antibody) at dilution of 1:200
IP Result of anti-SNAPIN (IP:FNab08060, 5ug; Detection:FNab08060 1:300) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08060(SNAPIN Antibody) at dilution of 1:200
- Background
- Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167).
