mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab08048(SMYD2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human heart using FNab08048(SMYD2 antibody) at dilution of 1:100
Background
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4'(H3K4me) and dimethylates histone H3 'Lys-36'(H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.