Products
SMYD2 antibody
- Product Name
- SMYD2 antibody
- Catalogue No.
- FNab08048
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SET and MYND domain containing 2
- Alternative Names
- KMT3C antibody
- UniProt ID
- Q9NRG4
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, WB, IF, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab08048(SMYD2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human heart using FNab08048(SMYD2 antibody) at dilution of 1:100
- Background
- Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4'(H3K4me) and dimethylates histone H3 'Lys-36'(H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
