Products
SMARCD1 antibody
- Product Name
- SMARCD1 antibody
- Catalogue No.
- FNab08010
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
- Alternative Names
- BAF60A antibody
- UniProt ID
- Q96GM5
- Observed MW
- 58 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab08010(SMARCD1 antibody) at dilution of 1:600
IP Result of anti-SMARCD1 (IP:FNab08010, 3ug; Detection:FNab08010 1:600) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human lymphoma using FNab08010(SMARCD1 antibody) at dilution of 1:50
- Background
- Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element(VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor(VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.
