Products
SMAD7 antibody
- Product Name
- SMAD7 antibody
- Catalogue No.
- FNab07999
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SMAD family member 7
- Alternative Names
- MADH7 antibody, MADH8 antibody
- UniProt ID
- O15105
- Observed MW
- 46 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab07999(SMAD7 antibody) at dilution of 1:600
- Background
- Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity).
