human brain tissue were subjected to SDS PAGE followed by western blot with FNab07968(SLC4A8 antibody) at dilution of 1:300
Background
Mediates electroneutral sodium-and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity(By similarity).