Products
SIX1 antibody
- Product Name
- SIX1 antibody
- Catalogue No.
- FNab07886
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SIX homeobox 1
- Alternative Names
- BOS3 antibody, DFNA23 antibody, Homeobox protein SIX1 antibody, Sine oculis homeobox homolog 1 antibody, SIX homeobox 1 antibody, SIX1 antibody, TIP39 antibody
- UniProt ID
- Q15475
- Observed MW
- 32-35 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
A2780 cells were subjected to SDS PAGE followed by western blot with FNab07886(SIX1 antibody) at dilution of 1:800
IP Result of anti-SIX1 (IP:FNab07886, 3ug; Detection:FNab07886 1:1000) with HEK-293 cells lysate 2560ug.
- Background
- Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2(By similarity). Regulates the expression of CCNA1.
