Products
SIGMAR1 antibody
- Product Name
- SIGMAR1 antibody
- Catalogue No.
- FNab07864
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- sigma non-opioid intracellular receptor 1
- Alternative Names
- FLJ25585 antibody, hSigmaR1 antibody, OPRS1 antibody, SIG 1R antibody, Sigma 1 type opioid receptor antibody, Sigma1 receptor antibody, Sigma1R antibody, SIGMAR1 antibody, SR BP antibody, SR BP1 antibody, SR31747 binding protein antibody, SRBP antibody
- UniProt ID
- Q99720
- Observed MW
- 27 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab07864(SIGMAR1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver cancer using FNab07864(SIGMAR1 antibody) at dilution of 1:50
- Background
- Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration(PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria(By similarity).
