Products
SHP2 antibody
- Product Name
- SHP2 antibody
- Catalogue No.
- FNab07854
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- protein tyrosine phosphatase, non-receptor type 11
- Alternative Names
- BPTP3 antibody, CFC antibody, NS1 antibody, PTP 1D antibody, PTP 2C antibody, PTP2C antibody, PTPN11 antibody, SH PTP2 antibody, SH PTP3 antibody, SHP 2 antibody, SHP2 antibody, SHPTP2 antibody
- UniProt ID
- Q06124
- Observed MW
- 68kDa, 53kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07854(PTPN11 antibody) at dilution of 1:500
IP Result of anti-SHP2 (IP:FNab07854, 4ug; Detection:FNab07854 1:1000) with HEK-293 cells lysate 2800ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab07854(PTPN11 antibody) at dilution of 1:100
Immunofluorescent analysis of Hela cells, using FNab07854(PTPN11 antibody)at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Background
- PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism(PMID:19017799). Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions(PMID:21576358). Defects in PTPN11 are the cause of LEOPARD syndrome type 1(LEOPARD1), Noonan syndrome type 1(NS1), juvenile myelomonocytic leukemia(JMML) and metachondromatosis(MC). It has 3 isoforms produced by alternative splicing.
