Products
SH3BP4 antibody
- Product Name
- SH3BP4 antibody
- Catalogue No.
- FNab07830
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SH3-domain binding protein 4
- Alternative Names
- BOG25 antibody, EHB10 antibody, TTP antibody
- UniProt ID
- Q9P0V3
- Observed MW
- 120 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07830(SH3BP4 antibody) at dilution of 1:300
IP Result of anti-SH3BP4 (IP:FNab07830, 4ug; Detection:FNab07830 1:300) with mouse lung tissue lysate 3600ug.
- Background
- May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
