HL-60 cells were subjected to SDS PAGE followed by western blot with FNab07617(SBDS antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gastric cancer using FNab07617(SBDS antibody) at dilution of 1:50
Background
This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located.