Products
RUNX1T1 antibody
- Product Name
- RUNX1T1 antibody
- Catalogue No.
- FNab07535
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- runt-related transcription factor 1; translocated to, 1(cyclin D-related)
- Alternative Names
- AML1T1 antibody, CBFA2T1 antibody, CDR antibody, ETO antibody, MTG8 antibody, ZMYND2 antibody
- UniProt ID
- Q06455
- Observed MW
- 70-75 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab07535(RUNX1T1 antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab07535(RUNX1T1 Antibody) at dilution of 1:50
- Background
- Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Can repress transactivation mediated by TCF12(PubMed:16803958). Acts as a negative regulator of adipogenesis(By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal(PubMed:23812588).
