Products
RSPO2 antibody
- Product Name
- RSPO2 antibody
- Catalogue No.
- FNab07511
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- R-spondin 2 homolog
- Alternative Names
- CRISTIN2 antibody, hRspo2 antibody, R spondin 2 antibody, Roof plate specific spondin 2 antibody, RSPO2 antibody
- UniProt ID
- Q6UXX9
- Observed MW
- 33 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:3000; IP: 1:500-1:1000
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07511(RSPO2 antibody) at dilution of 1:1000
IP Result of anti-RSPO2 (IP:FNab07511, 4ug; Detection:FNab07511 1:500) with mouse brain tissue lysate 2640ug.
- Background
- Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
