Products
RPE65 antibody
- Product Name
- RPE65 antibody
- Catalogue No.
- FNab07401
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- retinal pigment epithelium-specific protein 65kDa
- Alternative Names
- LCA2 antibody, mRPE65 antibody, rd12 antibody, Retinoid isomerohydrolase antibody, Retinol isomerase antibody, RP20 antibody, RPE65 antibody, sRPE65 antibody
- UniProt ID
- Q16518
- Observed MW
- 65kd,61kd
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:5000
Validated Images
Y79 cells were subjected to SDS PAGE followed by western blot with FNab07401(RPE65 antibody) at dilution of 1:600
- Background
- Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A(all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH(isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
