Products
RIC8A antibody
- Product Name
- RIC8A antibody
- Catalogue No.
- FNab07295
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- resistance to inhibitors of cholinesterase 8 homolog A(C. elegans)
- UniProt ID
- Q9NPQ8
- Observed MW
- 58-62 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab07295(RIC8A antibody) at dilution of 1:200
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab07295(RIC8A antibody) at dilution of 1:50
- Background
- Guanine nucleotide exchange factor(GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex(By similarity). Also acts as an activator for G(q)-alpha(GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
