Products
RBL2 antibody
- Product Name
- RBL2 antibody
- Catalogue No.
- FNab07157
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- retinoblastoma-like 2(p130)
- Alternative Names
- FLJ26459 antibody, P130 antibody, pRb2 antibody, Rb2 antibody, RBL2 antibody, RBR 2 antibody, retinoblastoma like 2(p130) antibody, Retinoblastoma like protein 2 antibody
- UniProt ID
- Q08999
- Observed MW
- 130 kDa
Application
- Tested Applications
- ELISA
- Recommended dilution
- WB: 1:200-1:2000
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab07157(RBL2 Antibody) at dilution of 1:1000
- Background
- Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
