Products
RAIDD antibody
- Product Name
- RAIDD antibody
- Catalogue No.
- FNab07092
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CASP2 and RIPK1 domain containing adaptor with death domain
- Alternative Names
- CRADD antibody, RAIDD antibody
- UniProt ID
- P78560
- Observed MW
- 23 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab07092(CRADD antibody) at dilution of 1:1000
IP Result of anti-RAIDD (IP: FNab07092, 3ug; Detection:1 FNab07092 1:1000) with mouse kidney tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab07092(CRADD antibody) at dilution of 1:100
- Background
- RAIDD, also named as CRADD, is an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1. It is a negative regulator of the CARMA1 signalosome and suppressor of Th1-and Th17-mediated inflammatory responses.
