Products
PTPN22 antibody
- Product Name
- PTPN22 antibody
- Catalogue No.
- FNab06936
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- protein tyrosine phosphatase, non-receptor type 22(lymphoid)
- Alternative Names
- PTPN8 antibody
- UniProt ID
- Q9Y2R2
- Observed MW
- 79-95 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab06936(PTPN22 antibody) at dilution of 1:600
IP Result of anti-PTPN22 (IP:FNab06936, 4ug; Detection:FNab06936 1:300) with Jurkat cells lysate 3080ug.
Immunohistochemistry of paraffin-embedded human lymphoma using FNab06936(PTPN22 antibody) at dilution of 1:50
- Background
- Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).
