Products
PTBP1 antibody
- Product Name
- PTBP1 antibody
- Catalogue No.
- FNab06907
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- polypyrimidine tract binding protein 1
- Alternative Names
- PTB antibody
- UniProt ID
- P26599
- Observed MW
- 59.6 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:500-1:2000; IF: 1:20-1:200
Validated Images
BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab06907(PTBP1 antibody) at dilution of 1:3000
- Background
- Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10(PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site(IRES) and stimulates the IRES-mediated translation(PubMed:21518806).
