Products
Prealbumin/transthyretin antibody
- Product Name
- Prealbumin/transthyretin antibody
- Catalogue No.
- FNab06761
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 8E4
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- transthyretin
- Alternative Names
- ATTR antibody, HsT2651 antibody, PALB antibody, Prealbumin antibody, TBPA antibody, transthyretin antibody, TTR antibody
- UniProt ID
- P02766
- Observed MW
- 16kd
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab06761(TTR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab06761(TTR Antibody) at dilution of 1:50
- Background
- Transthyretin(TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition(amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related(AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal(HTDE) and carpal tunnel syndrome type 1(CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.(22103483)
