Products

anti- PPP1R9B antibody

FNab06711 Catalogue No.
Synonyms
PPP1R6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC, IP
Product Information
Product Name
anti- PPP1R9B antibody
Catalogue No.
FNab06711
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments(F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1(By similarity). Required for hepatocyte growth factor(HGF)-induced cell migration.
Immunogen Information
Immunogen
protein phosphatase 1, regulatory(inhibitor) subunit 9B
Synonyms
PPP1R6
Observed MW
120-130 kDa
Application
Tested Application
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Uniprot information
UniProt ID
Q96SB3
Images
Immunohistochemistry of paraffin-embedded human brain using FNab06711(PPP1R9B antibody) at dilution of 1:50
IP Result of anti-PPP1R9B (IP:FNab06711, 4ug; Detection:FNab06711 1:300) with mouse brain tissue lysate 6000ug.
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab06711(PPP1R9B antibody) at dilution of 1:500