Products
POLR3K antibody
- Product Name
- POLR3K antibody
- Catalogue No.
- FNab06634
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- polymerase(RNA) III(DNA directed) polypeptide K, 12.3 kDa
- Alternative Names
- C11 antibody, C11 RNP3 antibody, hRPC11 antibody, HsC11p antibody, My010 antibody, POLR3K antibody, RNA polymerase III subunit C10 antibody, RNA polymerase III subunit C11 antibody, RPC10 antibody, RPC11 antibody, RPC12.5 antibody
- UniProt ID
- Q9Y2Y1
- Observed MW
- 12 kDa
Application
- Tested Applications
- ELISA, IHC, IF, WB
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500
Validated Images
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06634(POLR3K Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gliomas using FNab06634(POLR3K antibody) at dilution of 1:100
- Background
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).
