Products

anti- PMEPA1 antibody

FNab06569 Catalogue No.
Synonyms
STAG1, TMEPAI
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC, IF
Product Information
Product Name
anti- PMEPA1 antibody
Catalogue No.
FNab06569
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).
Immunogen Information
Immunogen
prostate transmembrane protein, androgen induced 1
Synonyms
STAG1, TMEPAI
Observed MW
32 kDa
Application
Tested Application
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Uniprot information
UniProt ID
Q969W9
Images
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab06569(PMEPA1 antibody) at dilution of 1:50
L02 cells were subjected to SDS PAGE followed by western blot with FNab06569(PMEPA1 Antibody) at dilution of 1:600