Products

anti- PLEKHO1 antibody

FNab06543 Catalogue No.
Synonyms
CKIP1, OC120
Host
Rabbit
Reactivity
Human, Mouse
Isotype
IgG
Tested Application
ELISA, WB
Product Information
Product Name
anti- PLEKHO1 antibody
Catalogue No.
FNab06543
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein(CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2(CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity(plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Immunogen Information
Immunogen
pleckstrin homology domain containing, family O member 1
Synonyms
CKIP1, OC120
Observed MW
46,90 kDa
Application
Tested Application
ELISA, WB
Recommended dilution
WB: 1:500-1:2000
Uniprot information
UniProt ID
Q53GL0
Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab06543(PLEKHO1 antibody) at dilution of 1:300