Products
Piezo1 antibody
- Product Name
- Piezo1 antibody
- Catalogue No.
- FNab06435
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- family with sequence similarity 38, member A
- Alternative Names
- FAM38A antibody, KIAA0233 antibody
- UniProt ID
- Q92508
- Observed MW
- 250kd
Application
- Tested Applications
- ELISA, WB,IHC
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:50-1:500
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06435(Piezo1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human brain tissue slide using FNab06435(FAM38A Antibody) at dilution of 1:200
- Background
- Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
