mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab06421(PIK3R3 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human brain cancer using FNab06421(PIK3R3 antibody) at dilution of 1:100
Background
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.