mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab06303(PELI1 antibody) at dilution of 1:400
IP Result of anti-PELI1 (IP:FNab06303, 4ug; Detection:FNab06303 1:300) with SH-SY5Y cells lysate 3000ug.
Background
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.