Products
PDE9A antibody
- Product Name
- PDE9A antibody
- Catalogue No.
- FNab06263
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- phosphodiesterase 9A
- Alternative Names
- HSPDE9A2 antibody, PDE9A antibody, phosphodiesterase 9A antibody
- UniProt ID
- O76083
Application
- Tested Applications
- ELISA, IF, IHC
- Recommended dilution
- IHC: 1:100-1:200; IF: 1:50-1:500
Validated Images
Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using FNab06263(PDE9A Antibody) at dilution of 1:200
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed A549 cells using FNab06263 (PDE9A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity).
