HeLa cells were subjected to SDS PAGE followed by western blot with FNab06239(PDCD4 antibody) at dilution of 1:3000
IP Result of anti-PDCD4 (IP:FNab06239, 4ug; Detection:FNab06239 1:3000) with HeLa cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab06239(PDCD4 antibody) at dilution of 1:50
Background
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA(By similarity).