Products
PARP3 antibody
- Product Name
- PARP3 antibody
- Catalogue No.
- FNab06158
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- poly(ADP-ribose) polymerase family, member 3
- Alternative Names
- ADPRT3 antibody, ADPRTL3 antibody
- UniProt ID
- Q9Y6F1
- Observed MW
- 60-62 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
human kidney tissue were subjected to SDS PAGE followed by western blot with FNab06158(PARP3 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab06158(PARP3 antibody) at dilution of 1:50
- Background
- Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
