Products
NUMBL antibody
- Product Name
- NUMBL antibody
- Catalogue No.
- FNab05917
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- numb homolog(Drosophila)-like
- UniProt ID
- Q9Y6R0
- Observed MW
- 65-70 kDa
Application
- Tested Applications
- ELISA, IF, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05917(NUMBLIKE Antibody) at dilution of 1:2000
IP result of anti-NUMBL(IP:FNab05917, 4ug; Detection:FNab05917 1:1000) with HeLa cells lysate 2800 ug
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab05917(NUMBLIKE Antibody) at dilution of 1:50
- Background
- Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
