Products
NTHL1 antibody
- Product Name
- NTHL1 antibody
- Catalogue No.
- FNab05883
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- nth endonuclease III-like 1(E. coli)
- Alternative Names
- NTH1 antibody, OCTS3 antibody
- UniProt ID
- P78549
- Observed MW
- 34 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
Y79 cells were subjected to SDS PAGE followed by western blot with FNab05883(NTHL1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gliomas using FNab05883(NTHL1 antibody) at dilution of 1:50
- Background
- Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic(AP) lyase function that catalyzes the first step in base excision repair(BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine(8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
