Products
NR2C1 antibody
- Product Name
- NR2C1 antibody
- Catalogue No.
- FNab05840
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- nuclear receptor subfamily 2, group C, member 1
- Alternative Names
- TR2 antibody
- UniProt ID
- P13056
- Observed MW
- 52kd
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab05840(NR2C1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05840(NR2C1 antibody) at dilution of 1:50 Heat mediated antigen retrieved with Citric acid buffer, pH6.0
- Background
- Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements(HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED(direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
