Products
NR1H3 antibody
- Product Name
- NR1H3 antibody
- Catalogue No.
- FNab05836
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 7D2
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- nuclear receptor subfamily 1, group H, member 3
- Alternative Names
- Liver X receptor alpha antibody, LXR a antibody, LXRA antibody, NR1H3 antibody, Oxysterols receptor LXR alpha antibody, RLD 1 antibody
- UniProt ID
- Q13133
- Observed MW
- 48 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:200-1:1000; IF: 1:10-1:100
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05836(NR1H3 antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells using FNab05836( NR1H3 Antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L)
- Background
- Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
