Products
NOTCH3 antibody
- Product Name
- NOTCH3 antibody
- Catalogue No.
- FNab05800
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Notch homolog 3
- Alternative Names
- CADASIL antibody, CASIL antibody, Notch 3 antibody, Notch homolog 3 antibody, NOTCH3 antibody
- UniProt ID
- Q9UM47
- Observed MW
- 250-260 kDa, 100 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500
Validated Images
COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab05800(NOTCH3 antibody) at dilution of 1:500
IP Result of anti-NOTCH3 (IP:FNab05800, 4ug; Detection:FNab05800 1:500) with HeLa cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05800(NOTCH3 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).
