Products
NLRP2 antibody
- Product Name
- NLRP2 antibody
- Catalogue No.
- FNab05758
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- NLR family, pyrin domain containing 2
- Alternative Names
- NALP2 antibody, NBS1 antibody, PAN1 antibody, PYPAF2 antibody
- UniProt ID
- Q9NX02
- Observed MW
- 105-110 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab05758(NLRP2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human placenta using FNab05758(NLRP2 antibody) at dilution of 1:50
- Background
- Suppresses TNF-and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
