Products
NF2 antibody
- Product Name
- NF2 antibody
- Catalogue No.
- FNab05685
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- neurofibromin 2(merlin)
- Alternative Names
- SCH antibody, ACN antibody, BANF antibody, Merlin antibody, Neurofibromin 2 antibody, neurofibromin 2(merlin) antibody, NF2 antibody
- UniProt ID
- P35240
- Observed MW
- 66-70 kDa
Application
- Tested Applications
- ELISA, WB, IHC,IP,IF
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab05685(NF2 antibody) at dilution of 1:1000
IP Result of anti-NF2 (IP:FNab05685, 4ug; Detection:FNab05685 1:600) with HeLa cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded rat brain tissue slide using FNab05685(NF2 Antibody) at dilution of 1:50
- Background
- Probable regulator of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
