Products
NEUROD1 antibody
- Product Name
- NEUROD1 antibody
- Catalogue No.
- FNab05674
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- neurogenic differentiation 1
- Alternative Names
- BHLHA3 antibody, ?NEUROD antibody, Neurogenic differentiation factor 1 antibody, NEUROD1 antibody, Class A basic helix-loop-helix protein 3 antibody, bHLHa3 antibody, NDF1 antibody
- UniProt ID
- Q13562
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
Y79 cells were subjected to SDS PAGE followed by western blot with FNab05674(NEUROD1 antibody) at dilution of 1:200
IP Result of anti-NEUROD1 (IP:FNab05674, 3ug; Detection:FNab05674 1:200) with Y79 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab05674(NEUROD1 antibody) at dilution of 1:50
- Background
- Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis(By similarity).
